Recently, in comparative genomics, a lot of work is being done in estimating genome size variation between different species. k-mer frquencies are being particularly utilized to calculate variations across species. Sun H. et. al.(2018) have developed a software called findGSE to calculate such variation.
The package has been written in R language and is above all the softwares being recently used to calculate genome size variation. They have done the analysis for 89 arabidopsis accessions as well as for human genomes which shows that geographical variation plays a crucial role in shaping variation across different genomes.
The software is available at the following URL:https://github.com/schneebergerlab/findGSE and supports both linux and Mac systems.
Sun H. et al.(2018) findGSE estimating genome size variation within human and arabidopsis using k-mer frequencies. Bioinformatics 34(4): 550-557.