Recently two main types of methods are being used for protein loop predictions- knowledge based and ab-initio. Till now, knowledge based methods utilize  protein sequences of similiar lengths  for prediction of protein loops. Ab-initio methods computationally generate protein structures.

          Marks et. al. (2017) have made a software called sphinx which utilizes both these methods to generate structures. It can be used for difficult tasks like antibody predictions.The software is available at the following URL:


Marks C Sphinx: Merging knowlwdge - based and ab initio approaches to improve protein loop prediction. Bioinformatics 33 (9):1346-1353




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